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settings Open AccessReview Physical Activity and Diet Shape the Immune System during Aging
Home » may 2020- immune system » settings Open AccessReview Physical Activity and Diet Shape the Immune System during Aging

settings Open AccessReview Physical Activity and Diet Shape the Immune System during Aging

May 4, 2020 10:03 am Comments Off on settings Open AccessReview Physical Activity and Diet Shape the Immune System during Aging morw31

Physical Activity and Diet Shape the Immune System during Aging

by Christopher Weyh ,Karsten Krüger  and Barbara Strasser

 
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Nutrients. Published: 28 February 2020

Abstract

With increasing age, the immune system undergoes a remodeling process, termed immunosenescence, which is accompanied by considerable shifts in leukocyte subpopulations and a decline in various immune cell functions. Clinically, immunosenescence is characterized by increased susceptibility to infections, a more frequent reactivation of latent viruses, decreased vaccine efficacy, and an increased prevalence of autoimmunity and cancer. Physiologically, the immune system has some adaptive strategies to cope with aging, while in some settings, maladaptive responses aggravate the speed of aging and morbidity. While a lack of physical activity, decreased muscle mass, and poor nutritional status facilitate immunosenescence and inflammaging, lifestyle factors such as exercise and dietary habits affect immune aging positively. This review will discuss the relevance and mechanisms of immunoprotection through physical activity and specific exercise interventions. In the second part, we will focus on the effect of dietary interventions through the supplementation of the essential amino acid tryptophan, n-3 polyunsaturated fatty acids, and probiotics (with a special focus on the kynurenine pathway).

Posted in: may 2020- immune system
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