egrepa
  • Home
  • EGREPA
    • Constitution
    • Mission statement
    • EURAPA
    • EURAPA Journal
    • EURAPA Journal
    • EURAPA Abstract
    • History – EURAPA
  • PROJECTS
    • CA20104
    • PA4AGE
    • Actimentia
    • Whole
    • Active I
  • RESEARCH
    • young researchers
      • Congress on-line 2021 Young researcher award
      • The winner of Young Researcher Award
    • Research Centers
  • CONGRESSES & SYMPOSIUMS
    • wingate 2014
    • Symposium 2017
      • Symposium 2017 – Abstract
    • Conference Announcement 2018
    • Symposium 2019
    • Congress on-line 2021
  • Home
  • EGREPA
    • Constitution
    • Mission statement
  • EURAPA
    • EURAPA Journal
    • EURAPA Abstract
    • History – EURAPA
  • PROJECTS
    • Whole
    • Active I
    • Actimentia
  • RESEARCH
    • Young Researchers
      • The winner of Young Researcher Award
    • Research Centers
  • CONGRESSES & SYMPOSIUMS
    • wingate 2014
    • Symosium 2015 – Abstract
    • Symposium 2017
      • Symposium 2017 – Abstract
    • Conference Announcement 2018
    • Symposium 2019
egrepa
  • Home
  • EGREPA
    • Constitution
    • Mission statement
  • EURAPA
    • EURAPA Journal
    • EURAPA Abstract
    • History – EURAPA
  • PROJECTS
    • Whole
    • Active I
    • Actimentia
  • RESEARCH
    • Young Researchers
      • The winner of Young Researcher Award
    • Research Centers
  • CONGRESSES & SYMPOSIUMS
    • wingate 2014
    • Symosium 2015 – Abstract
    • Symposium 2017
      • Symposium 2017 – Abstract
    • Conference Announcement 2018
    • Symposium 2019
  • Home
  • EGREPA
    • Constitution
    • Mission statement
  • EURAPA
    • EURAPA Journal
    • EURAPA Abstract
    • History – EURAPA
  • PROJECTS
    • Whole
    • Active I
    • Actimentia
  • RESEARCH
    • Young Researchers
      • The winner of Young Researcher Award
    • Research Centers
  • CONGRESSES & SYMPOSIUMS
    • wingate 2014
    • Symosium 2015 – Abstract
    • Symposium 2017
      • Symposium 2017 – Abstract
    • Conference Announcement 2018
    • Symposium 2019
Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion
Home » may 2019 - physical activity after stroke » Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

May 6, 2019 12:10 pm Comments Off on Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion morw31

Min Cheol Chang, Chae Ri Park, Seung Hwa Rhie, Woo Hyun Shim Dae Yul Kim MD

Year : 2019  |  Volume : 14  |  Issue : 7  |  Page : 1230-1236

Abstract

The neuroprotective function of macrophage migration inhibitory factor (MIF) in ischemic stroke was rarely evaluated. This study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor (BDNF) in the ischemic area. A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion (MCAO)-Ex, n = 10), ischemia and sedentary group (MCAO-St, n = 10), sham-surgery and exercise group (Sham-Ex, n = 10), or sham-surgery and sedentary group (Sham-St, n = 10). The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes, whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without MCAO. Rats in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive days. After reperfusion, the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St group. The expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex group. Increased MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct region. There was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St groups. Our study demonstrated that early exercise (initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic stroke. Furthermore, the increased levels of MIF and BDNF in the peri-infarct region (penumbra) may be one of the mechanisms of enhanced neurological function recovery. All experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea (2016-12-126).

Posted in: may 2019 - physical activity after stroke, Uncategorized
« Previous
Next »

About


View all posts by morw31

  • membership
  • contact
  • links
  • Main theme of previous months
  • Home
  • Active I
  • congresses
  • contact
  • EGREPA
  • membership
  • publications
  • Research Centers
  • Societies
  • Whole
  • young researchers
we will be happy to hear from you
All rights reserved to EGREPA©
Scroll to top
Skip to content
Open toolbar Accessibility Tools

Accessibility Tools

  • Increase TextIncrease Text
  • Decrease TextDecrease Text
  • GrayscaleGrayscale
  • High ContrastHigh Contrast
  • Negative ContrastNegative Contrast
  • Light BackgroundLight Background
  • Links UnderlineLinks Underline
  • Readable FontReadable Font
  • Reset Reset